Lub sijhawm twg ntawm ib hnub koj yuav tsum tau noj urolithin a?

"Ib qho kev sib txuas ob zaugUrolithin a (ua ntej)Nrog rau pluas tshais thaum sawv ntxov tuaj yeem nce cov ntshav ntshav siab tshaj plaws los ntawm 40% thiab txhim kho vs-

1.Vim Li Cas Sawv ntxov Siv tau zoo dua (raws li Corrmadian atherosclerosis)

Peb qhov loj mechanism:

{1. mitochondrial circadian atherm squchronization

Tib neeg mitochondrial kev ua si nyob rau yav sawv ntxov (6: {00-10}} Kuv), thaum ua haujlwm ntawm actophagy yog qhov siab tshaj plaws.

Kev ua yeeb yaj kiab thaum sawv ntxov ↑ 27% (cov khoom muaj protein kev tswj hwm mitochondrial autophagy) [DYART}, Cell metabolism 2018 4}}]

Nqaij Bioples ntawm UA cov pab pawg sawv cev sawv cev uas Ampk phosphorylation qib yog 68% siab tshaj qhov ntawm cov pab pawg yav tsaus ntuj [} {1}., 2019, khoom]

2.} }ircized rog solubility thiab nqus

Ua yog cov roj-soluble molecule, thiab cov rog noj tshais tuaj yeem txhim kho bioavailability:

3.} Tsis txhob muaj kev pheej hmoo ntawm kev pw tsaug zog

High-dose ua (ntau dua los yog sib npaug nrog 500mg) tuaj yeem qhib lub ampk txoj kev, thiab noj thaum hmo ntuj yog txuam nrog cov kev pheej hmoo hauv qab no:

Pw latency yog ntev ntev los ntawm 23% [schmidt thiab al .}, chronobiology rau 2021]

Melatonin Peak concentration txo qis los ntawm 19% [tib txoj kev kawm, Daim duab .2]

2.Thaum twg yuav kho koj cov urolithin a

Cov xwm txheej tshwj xeeb uas yuav tsum tau hloov kho:

Cov ntsiab lus:

Zam Txim Noj Tom Qab 21: {{{{1} → in cuam tshuam nrog Core Lub Cev Ntsuas Kub (cov kws kho mob

3.Yuav Ua Li Cas Khov Urolithin A nrog zaub mov

Synero ua ke:

Tus khub zoo tshaj plaws (nce ntxiv nqus los ntawm 28-32%):

5-10 g noj qab haus huv rog= 1 boiled qe / 1 teaspoon txiv ntseej roj

Mechanism: rog stimulates bile secretion → txhawb nqa cov khoom siv roj kib-soluble [Rebul thiab}, EUR J NEW 2021]

Kev sib txuas ua ke uas yuav tsum zam:

Qhov tseeb txog kev sib cav sib ceg:

Kev yoo mov nqus cov nqi: 72% ± 11%

Kev nqus tus nqi nrog cov khoom noj muaj roj me: 94% ± 9% (p<0.01)

FAQ:

Q: Puas yog ua tau los noj nws tom qab noj hmo?

A: Tsis nyiam {. Cov pab pawg noj nws ntawm 23: {vs {}} Cov pab pawg noj nws thaum sawv ntxov:

Ntshav AUC₀₋₂₄ ↓ 41% [Andreux Khoom . cov ntaub ntawv]

Psg kuaj pom ib qho 14-} feeb txo qis hauv kev pw tsaug zog hauv kev pw tsaug zog [Schmidt 2021]

Q: Dab tsi yog lub sijhawm zoo tshaj plaws rau cov neeg tawm dag zog?

A: Cov ntaub ntawv ua pov thawj raws li:

Cov kws qhia thaum sawv ntxov: Kev kawm tom qab kev cob qhia tshais + ua

Cov kws qhia yav tav su: Kev kawm noj mov tom qab + ua ntej (siv cov qhov rai glut4 transmocation) [}, J Physiol 2013]

Q: Puas yog lwm cov khoom siv yuav tsum tau hloov kho?

A: Kev tseem ceeb ua ke:

Ntxiv Khoom Hom Sij Hawm Sij Hawm

Calcium / Magnesium / Hlau Loj dua los yog sib npaug rau 2 teev sib tw rau cov neeg thauj khoom sib txawv

Vitamin D tuaj yeem coj ua ke co-tswj tus neeg siv lub cajg

Probiotics txhua lub sijhawm tsis muaj kev sib cuam tshuam

Ntawv Sawv cev