1. Kev sib txheeb ntawm kev laus tawv nqaij thiab Mitochondria
Daim tawv nqaij, lub cev loj tshaj plaws hauv tib neeg lub cev, muaj tus nqi siab dua qub, muaj kev rov ua dua tshiab Epidermis uas nws rov qab ua dua tshiab Epidermal progenitor hlwb yog cov nquag nquag thiab metabolically nquag, thiab yog nyob ntawm Adenosine Triphosphate (ATP) rau lub zog yuav tsum tau ua.
Adenosine Triphoscephate yog ib lub nucleotide uas khaws cia thiab cov khoom xa tuaj hluav taws xob zoo li cov khoom siv "molecular loj hloov chaw. Qhov laj thawj yog vim li cas nws tuaj yeem muab cov qauv molecular tuaj yeem sau ua- sawv cev rau qhov siab tshwj xeeb hu ua lub siab- Zog- Zog- Zog- Zog} Thaum siab - Zog} Lub Zog Phosphate Bonds tau tawg, muaj lub zog loj.
Mitochondria, raws li ob npaug - Mem membrane, muaj nyob hauv cytoplasm ntawm yuav luag txhua eukaryotic hlwb. Thaum ATP yog tsim los ntawm oxidative phosphorylation (Oxphos) hauv lub zog thiab steroid thiab steroid cov haujlwm zoo xws li apoptosis thiab calcium Kos Npe.
Ntuj los ntawm kev sib tw ntawm oxpholos muaj cov oxygen hom (Ros), xws li superoxide oneion, thiab painten oxygen, thiab page li kev puas tsuaj ntawm macromolecules thiab cov qauv cellular. Oxidative kev puas tsuaj los ntawm Mitochondrial Ros ntau lawm yog qhov tseem ceeb molecular lub hauv paus rau ntau yam kev mob pathophysiological, suav nrog kev laus thiab mob qog noj ntshav.
2. Cov nyhuv ntawm kev ua kom zoo nkauj rau kev laus tawv nqaij
Ntxiv rau lub sij hawm inevrass -}}}}}} {}}}}}} lub hnub uva thiab UVB hluav taws xob.
Ultraviolet Rays nyob rau hauv lub hnub ci tuaj yeem txhim kho kev ua si ntawm Tyrosinase, yog li nce cov synthesis ntawm melanin thiab nrawm ntawm kev laus tawv nqaij thiab nrawm nrawm. Tsis tas li ntawd, txij li kev soj ntsuam yog qhov kev ua raws li, nws tau tshaj tawm nyob rau cov laus cov laus uas muaj lub hnub nyoog ntev. Ob qho tib si intrinsic thiab ib puag ncig cuam tshuam rau cov kab mob Epidermal thiab cov txheej txheem dermal ntawm daim tawv nqaij. Histologically, Kev laus raws sijhawm yog tus cwj pwm los ntawm cov cim Epidermal thinning manifested los ntawm dryness thiab wrinkling.
Hauv kev sib piv, daim tawv nqaij muaj tuab, tawv zoo nkauj nrog tob wrinkles thiab tsis sib xws pigmentation. Ntawm cov qib molecular, cov tawv nqaij laus yog tus cwj pwm los ntawm kev puas tsuaj ntawm Mitochondria, ploj ntawm cov mtdna, muaj kev ntxhov siab oxidative hauv cov ncauj lus dermis thiab epidermis. Kev laus cuam tshuam rau daim tawv nqaij tiv thaiv cov kws ua physicochemical thiab kev ua txhaum cai, zoo li nws thermorefatory, cov kheej, tsis muaj zog, muaj zog thiab cov tshuaj hormonal.
3. Lub cev tsoos tsho thiab tshuaj pleev thaiv hnub qub
Nyob rau hauv dav dav, hnub ci tau muab faib ua lub cev Sunscreens thiab Tshuaj lom Sunscreens:
Kev Tiv Thaiv Lub Cev Lub Cev
Zam kev mus ncig thaum lub hnub muaj zog tshaj, feem ntau thaum 9:00 teev sawv ntxov txog 2:00 teev tsaus ntuj, thaum ultraviolet rays yog kuj muaj zog.
Thaum tawm mus, koj tuaj yeem npaj cov khaub ncaws tiv thaiv hnub, lossis npaj ib qho parasol, lossis hnav looj tsom iav, lub ntsej muag lossis qee yam.
Tshuaj Lom Ua Si
Tshuaj lom zem hnub ci yog qhov peb paub ua tshuaj pleev thaiv hnub. Sunscreen Ua cov yeeb yaj kiab ua yeeb yaj kiab ntawm ntawm peb daim tawv nqaij tiv thaiv kev tiv thaiv UV duab.
Thaum xaiv cov tshuaj pleev thaiv hnub, nws yog qhov zoo tshaj plaws los xaiv ib qho uas tiv thaiv kev tawm tsam ob qho UVA thiab UVB.
4. Qhov kev sib txheeb ntawm Mitochondria thiab cov kab mob ntawm daim tawv nqaij
In addition to skin aging and cancer, mitochondrial dysfunction has been associated with a variety of common and rare skin disorders, which can be broadly divided into three categories: skin manifestations of primary mitochondrial disorders, skin disorders caused by mitochondrial dysfunction, and genetic skin disorders Performance.
Clinically, cov kev tsis sib haum no tuaj yeem tshwm sim ua cov plaub hau txawv txav, o, khaus, xiav {{{ece {ece eyed extremicity). Feem ntau ntawm cov kab hauv qab molecular tau raug txheeb xyuas, feem ntau yog koom nrog kev sib hloov pauv ntawm mitochondenity, thiab kev sib cav sib ceg ntawm nuclear- encoded mitochondrial proteins. Tsis tas li ntawd, dysregulation ntawm lwm cov mitochondrial metabolism pathways thiab cov protein kuj tau muaj kev cuam tshuam.
Nws tuaj yeem pom tau tias kev sib txheeb ntawm Mitochondria thiab daim tawv nqaij yog qhov sib ze heev. Nws tsis yog txwv rau cov tawv nqaij laus uas peb feem ntau muaj kev txhawj xeeb txog. Hauv kev tshawb fawb, cov kws tshawb fawb kuj tseem muaj kev txhawj xeeb txog kev sib txheeb ntawm Mitochondria thiab cov kab mob ntawm daim tawv nqaij thiab mob cancer.
Raws li lub hnub nyoog nce, tus naj npawb ntawm mitochondria hauv tib neeg lub cev yuav maj mam tsawg dua, thiab ua haujlwm ntawm Mitochondlicial hluav taws xob yuav tseem qis dua ua ntej. Tom qab ntawd kev daws teeb meem yog txhawm rau txhim kho kev ua haujlwm ntawm mitochondrial ua haujlwm, lossis nce tus naj npawb ntawm mitochondria hauv tib neeg lub cev.
Uas tau hais tias, txhawb mitochondrial biogenemesis yog qhov tseem ceeb, akin rau qhov kev xav ntawm kev kho tau tag nrho qub qub los tsim cov tshuab tshiab tshiab.
5. NMN tuaj yeem qeeb tawv nqaij laus
Cell mitochondria tuaj yeem siv ncaj qhaNmn, Nmn tuaj yeem nce mitochondrial nad + qib txiav txim siab txog kev laus ntawm tib neeg lub hlwb thiab lub zog ntawm kev kho mob cell.
Nad +Ua txhaum li Fabkis hauv mitochondria los txhawb kev sib tw metabolic, NAD Kev laus thiab qhov siab- cov khoom noj muaj calories tuaj yeem txo qis qib Nad + hauv lub cev. Noj NAD + Boosters kuj tau txo cov zaub mov noj-}}}}}}} muaj peev xwm txhim kho cov nas laus, qhov kev tshawb fawb pom. Nad + khi rau cov enzymes thiab transfers tshuab hluav taws ntawm cov lwg me. Cov hluav taws xob yog cov khoom tsim ntawm lub zog ntawm tes. NAD + tej kev ua ntawm cov cell zoo li them lub roj teeb. Thaum lub tshuab hluav taws xob siv, cov roj teeb tuag. Hauv cov hlwb, NAD + nrog kev hloov hluav taws xob hauv tshuab hluav taws xob, uas muab lub zog rau hlwb. Nyob rau hauv txoj kev no, NAD + tuaj yeem txo qis lossis nce enzyme kev ua si, txhawb nqa noob hais tawm thiab kev taw qhia ntawm tes.
NAD + pab tswj DNA kev puas tsuaj. Raws li cov muaj sia, qee qhov tsis zoo, xws li hluav taws xob, xws li kev ua qias tuaj, thiab ua kom DNA tsis zoo DNA. Nov yog ib qho ntawm cov kev kwv yees. Yuav luag txhua lub hlwb muaj "molecular machinery" los kho qhov kev puas tsuaj no. Kev kho no NAD + thiab lub zog, yog li ntau dhau DNA kev puas tsuaj ntawm cov khoom muaj nuj nqis cellular. Ib qho tseem ceeb DNA kho cov protein, parp, kuj yog nyob ntawm NAD + rau kev ua haujlwm. Kev laus laus ua rau kev tsub zuj zuj ntawm DNA kev puas tsuaj hauv lub cev, nce rarp, thiab yog li ntawd qis nad + ntau. Txhua kauj ruam ntawm mitochondrial DNA kev puas tsuaj exacerbates qhov depletion no.
Peb yuav tsum lees paub tias nyob rau hauv cov ntsiab lus thev naus laus zis, NMN cov khoom lag luam tuaj yeem piav qhia kom meej dua rau General "anti {{{}}} kev laus khoom. Vim tias NMN cov khoom ua si ib qho anti - kev ua haujlwm "los ntawm sab hauv ntawm kev kho tib neeg DNA, daws cov teeb meem los ntawm lub hauv paus.
