Cov tsos mob ntawm NAd tsis txaus?

Nad + (Nicotinamide Adenine Cinucleotide)Yog cov tseem ceeb coenzyme ntawm cellular lub zog metabolism, ncaj qha tswj 400+ biochemical tshua tshua. Qhov kev kawm kawg hauv xwm metabolism qhia meej:

"NAD + qib poob sai nrog lub hnub nyoog: cov leeg nad + cov ntsiab lus ntawm ib tug 40%}}} xyoo 60% Thaum muaj hnub nyoog 60 xyoos" - ZHU li al., 2023

Nad plaub lub luag haujlwm Irreplacease

Mitochondrial fais fab cog roj

NAD + tsav lub saw hluav taws xob kom tsim kom muaj ATP, thiab thaum nws tsis txaus, ua haujlwm ntawm cov khoom siv hluav taws xob hluav taws xob yog ↓ 60% (GOES li al., Cell 2013)

Thiav protein sirtins actation hloov

Kev tswj hwm DNA kho thiab anti - pa taws txoj haujlwm, thiab sirtuins kev ua si, thiab sirtuins txoj kev ua yog ↓ 80% thaum tsis txaus (Verdin li al., Xwm 2020)

DNA kho cov khoom raw

100-150 nad + molecules tau noj rau txhua qhov kev kho ntawm DNA breakpoint (FANG li al., Science 2016)

Cov thawj tswj kev tswj hwm ntawm lub moos txheeb

Saib xyuas cov lus sib dhos ntawm lub moos: BMAL1 protein ntau (Ramsey li al., Science 2021)

Tus mob 9 tus mob tseem ceeb ntawm NAD + tsis muaj peev xwm

Perfistent kev qaug zog & cov kev ua si dhau kev chim siab plummeted

Mechanism: Mitochondial atp tus nqi ntawm myocardial thiab pob txha pob txha ↓ 45% thiab cov metabolism 2018)

Kev nthuav qhia kev nthuav dav: Kev ua pa tsis ntev tom qab nce ob lub davhlau ntawm cov ntaiv ntawm taw ntaiv, tseem muaj nkees thaum sawv ntxov

Cov haujlwm metabolic vau

Cov pov thawj tseem ceeb: ↓ 30% → SIFT1 inactivation → Insulin Confensitivity ↓ 50% (Yoshino li al., Xwm 2020)

Cov Kev Tshuaj Xyuas Kev Nyab Xeeb: Kev Ua Rog Rog Dawb + Txawv Kub Ua Haujlwm Cov Ntshav Qab Zib Ntshav Qab Zib

Lub hlwb huab thiab nco ploj

Neighchanism: Kev noj ntau dhau ntawm NAD + los ntawm Neuronal DNA kho enzyme paraptic muaj nuj nqi (hou li al., PNAS 2023)

Kev Tshawb Pom: NAD + nyob rau hauv lub hippochouth ntawm Alzheimer cov neeg mob raug txo los ntawm 40% (ntev li al., Nuron 2022)

Ncua rov qab los ntawm kev tawm dag zog

Cov leeg nqaij biopsy qhia tau hais tias tus nqi ntawm mitochondrial autophagy hauv NAD + Defient Kawm Ntawv yog ↓ 37% (Frederick li al., Daim Ntawv Qhia Txog Cell 2022)

Symptoms: muscle soreness lasts for >72 teev, lactate clearance lub sijhawm ob npaug

Cov Lus Sib Tham Crazytherm

Molecular txheej txheem: NAD + Regulates moos Acetylation, thiab tsis muaj peev xwm ua rau ib / sry quaj protcillation tsis meej (peek thiab al., Science 2021)

Kev tshwm sim: insomnia / awakening thaum ntxov / nruab hnub pw tsaug zog triad

Lwm cov tsos mob tseem ceeb

6 pawg nquag mus rau nad + tsis txaus

High - kev pheej hmoo pej xeem screening rooj

Yog tias muaj ntau dua los yog sib npaug rau 3 ntawm cov tsos mob saum toj no, qhov tshwm sim ntawm NAD + Qhov Tsis Txaus tau tshaj 82% (Trammell li al., Nat Commar 2023)

Rov kho NAD +: Los ntawm kev kuaj mob mus ua

Kev kuaj mob teeb meem thiab lwm txoj kev xaiv

Cov kev txwv ntawm kev kuaj tsev hauv tsev: NAD + ib nrab- lub neej tsuas yog siv sijhawm ntev 30 feeb, thiab ua kua rau cov leeg nqaij biople (Yang li al., Nat Protoc 2020)

Cov ntsuas indirectators indicators:

Ntshiab nicotinamide<30nmol/L (sensitivity 92%)

CD38 enzyme kev ua ↑ (tseem ceeb enzyme rau kev siv mob siab ntawm nad +)

Kev ua haujlwm ntawm cov txiaj ntsig ntawm cov phiaj xwm kev cuam tshuam

1. NAD + / Progursor ntxiv

Nad + Cov Tshuaj Pab Rau

NR (Nicotinamide Riboside)

NMN ({- nicotinamide mononucleotide)

2. Kev tawm dag zog synergistic nyhuv

Kev cob qhia HIIT rau 4 lub lis piam → Cov leeg nad + ↑ 30% + sirt1 kev ua si ↑ 50% (Frederick li al., 2022)

3. Kev noj zaub mov kom haum (cov nyhiliary)

200 ml mis ≈ 0.5 mg nr (400 khob yog xav tau kom ncav cuag cov koob tshuaj zoo)

100 g porcini ≈ 3 mg niacin (siab dua<1%)

Cov lus xaus

"NAD+ supplementation reverses muscle mitochondrial function in 55-year-old individuals to 35-year-old levels" – Elhassan et al., Nature Aging 2023

Ntawv Sawv cev