NMN yog cov lus luv ntawm nicotinamide mononauride, nrog molecular hnyav ntawm 334.2192. Nws yog ib qho tshuaj xam hniav hauv tib neeg lub cev thiab tseem nplua nuj nyob hauv qee cov txiv hmab txiv ntoo thiab zaub.
Nyob rau hauv tib neeg lub cev, NMN yog tus ua ntej NAD +, thiab nws txoj haujlwm tau xav txog los ntawm nad +.
NMN yog tus ua ntej ntawm NAD +
NAD + kuj tseem hu ua coenzyme ⅰ, nws lub npe tag nrho yog nicotinicanide adenine dinucleotoide, nws muaj nyob rau hauv txhua txhua cell thiab koom nrog ntau txhiab qhov kev tawm tsam.
NAD + yog ib qho tseem ceeb coenzyme ntawm TricarboxLic acid ncig, uas txhawb nqa cov metabolism acid, cov rog, thiab koom nrog synthesis ntawm lub zog;
NAD + yog tsuas yog substrate ntawm coenzyme Kuv tau noj cov enzymes (tsuas yog substrate tshiab {1}
Qhov cuam tshuam loj ntawm NAD + ntawm tib neeg lub cev
Lub voj voog tricarboxylic acid voj voog yog qhov kawg metabolic txoj kev ntawm peb lub cev loj (suab thaj, thiab cov amino acids) hauv cov suab thaj, lipids, thiab amino acids. Lub TrricarboxLic acid ncig ua ntau tshaj li 95% ntawm lub zog hauv lub cev. Nws yog lub zog hub ntawm lub cev muaj sia nyob.
Cov Khoom Noj Khoom Noj Muaj NMN
NMN yog ib qho quav tso rau hauv tib neeg lub cev, thiab qee cov txiv hmab txiv ntoo thiab zaub kuj yog cov nplua nuj nyob hauv.
| Khoom Noj Khoom Noj | Lub npe | mg / 100g {{{}}} zaub mov |
| Zaub | Edamame | 0.47-1.88 |
| Broccoli | 0.25-1.12 | |
| Cucunub Noob | 0.56 | |
| Dib | 0.65 | |
| Zaub qhwv | 0.0-0.90 | |
| Txiv | Avocado | 0.36-1.60 |
| Txiv | Txiv lws suav | 0.26-0.30 |
| Lwm | Nceb | 0.0-1.01 |
| Nqaij | Nqaij nyuj (nyoos) | 0.06-0.42 |
| Zaub mov ntawm hiav txwv | Tus cw | 0.22 |
Raws li FDA qhov sib txig sib luag, ib tug 70kg laus yuav tsum tau txhawb nrog 600mg ntawm NMN ib hnub. Txhawm rau ntxiv rau tib tus nqi ntawm NMN, ib tus neeg laus yuav tsum tau noj 32 ~ 128kg ntawm Edamame lossis 54 ~ 240kg ntawm zaub cob pob. Thiab qhov no tseem nyob rau hauv cov ntaub ntawv ntawm kev ua kom tiav kev nqus tau, uas yog obviously tsis muaj tseeb, thiab nws yog qhov tshwj xeeb rau kev ntxiv NMN los ntawm tsis} cov zaub mov.
Cov kev metabolic ntawm NMN hauv tib neeg lub cev
NAD + tau nrhiav pom thiab muaj npe thaum ntxov li xyoo 1904, thiab nws txoj haujlwm tau raug tshawb pom tas mus li. Cov kev tshawb fawb ntawm NAD + yug rau Nobel nqi zog yeej, yog li NAD + kuj tseem hu ua Noga qhov zoo.
NMN yog cov ua ntej ntawm NAD +, thiab nws muaj nuj nqi kuj tseem cuam tshuam los ntawm nad +. cov metabolism ntawm NNM thiab NAD + yog txuas ua ke.
Muaj peb txoj hauv kev ywj siab rau NAD + nyob rau hauv tib neeg lub cev: prefiss - Txoj kev huv si thiab khaws cov kev sib txuas lus zoo nkauj.
● PreCY -} Handler mus kom ze
Nws tau pom los ntawm preiss thiab hsndler xyoo 1957 ~ 1958, yog li nws tau tis npe ua ntej- tsheb txoj kev.
Txoj kev no pib los ntawm niacin, uas yog catalyzed los ntawm nicotinic acid phosphoriboside (NapnatiCed by Nicotinic Acid Mononuces
De Novo artthesis synwises
Txoj kev no tseem hu ua Kynurenine Txoj Kev Kynurenine.
Pib los ntawm Tryptophan tau noj hauv cov zaub mov, nws hloov mus rau hauv quinolinic acid tom qab dhau los ntawm nynurenine, l} kynurenine,}} acms ac}}
Lub ido thiab tdo txoj hauv kev ntawm tryptophan mus rau n- formenkynurenine pathwefy, thiab acms tseem tuaj yeem nkag mus rau hauv tricarboxylic acid voj voog.
● Kev rov kho cov kab hluavtaw
NAD + mus rau peb zaug kev noj hauv txoj hauv kev (Sirtuins, Parps, thiab tom qab ntawd ua rau muaj kev hloov pauv Nad + los ntawm catalyzed los ntawm catalyamide, thiab tom qab ntawd tau hloov pauv mus rau NMNAT1 ~ 3 enzymes kom ua tiav lub voj voog.
Cov kev tshawb fawb tau pom tias NAD + tsim los ntawm cov nyiaj txiag hluavtaws hauv tib neeg lub cev, thiab cov neeg ua haujlwm ntawm cov neeg ua haujlwm hauv lub voj voog no. Cov ntsiab lus ntawm NAD + tswj hwm qhov nyiaj seem nyob hauv peb txoj kev ywj pheej, thiab cov kev sib tw hluavtaws tseem ceeb yog qhov tseem ceeb ntawm NAD + hauv tib neeg lub cev. Nad + yuav raug muab tshaj ua ke 2 txog 4 zaug hauv ib tug 75kg laus kom ncav cuag ib theem ntawm 3G.
