Cordycepin hmoov

Cordycepin, tseem hu ua cordycepin, cordycepin, thiab cordycepin, muaj cov tshuaj formula C10H13N5O3 thiab yog thawj nucleoside tshuaj tua kab mob cais tawm los ntawm fungi.

Cordyceps sinensis polysaccharide yog ib qho chaw lees paub, polysaccharides, thiab cov tswv tsev loj ntawm lwm cov khoom noj khoom haus uas tau pom tshiab, Cordyceps sinensis polysaccharide raws li tonic uas txhawb nqa qib ntawm lub zog, kev loj hlob, kev ua siab ntev thiab lub zog hauv lub cev.

1. Kev tiv thaiv lub ntsws thiab lub raum
Hauv kev tshawb fawb ntawm cov tshuaj sab hnub poob, Ma Shumei thiab lwm tus pom tias cordycepin tuaj yeem txo cov mob ntsws ntsws, txhim kho lub ntsws cov qauv thiab kev hloov pauv ntawm cov kab mob fibrosis. Zhang Min thiab lwm tus tau pom tias qee qhov koob tshuaj cordycepin inhibited cov kab mob ua pa ntev ntawm kev mob ntsws asthma los ntawm kev siv tus qauv nas ntawm bronchial hawb pob, thiab tib lub sij hawm ua ke nrog glucocorticoids tuaj yeem cuam tshuam qhov contraction ntawm cov leeg nqaij, txo qhov tshwm sim ntawm hawb pob. , thiab txo qhov tshwm sim ntawm hawb pob. Airway remodeling muaj qee yam kev txhim kho. Cordycepin inhibits zus tau tej cov cytokines hauv COPD (mob obstructive pulmonary kab mob), txo o nyob ib ncig ntawm lub ntsws thiab cov hlab ntsha, thiab relieves pulmonary pathological hloov xws li epithelial hyperplasia.
2. Los tiv thaiv peb lub siab
Peb qhov siab yog cov ntsiab lus dav dav rau hyperlipidemia, ntshav siab thiab ntshav qab zib siab. Raws li kev tshawb fawb, kev sib sau ntawm peb cov kab mob no tsis yog kev sib tsoo, thiab peb qhov cuam tshuam rau ib leeg ua khub. Cov kev tshawb fawb tau pom tias cordycepin muaj cov txiaj ntsig zoo ntawm kev txo cov ntshav lipids, thiab nws tseem cuam tshuam rau cov rog rog thaum txo cov ntshav lipids. Xyoo 2008, Zhao Haiyan thiab lwm tus tau pom tias cordycepin tuaj yeem muaj qee yam kev tiv thaiv ntawm pancreatic hlwb nyob rau hauv cov ntshav siab. Hauv kev kho mob ntawm atherosclerosis thaum ntxov, cordycepin inhibited inflammatory teb thiab tiv thaiv kev ncaj ncees ntawm vascular endothelium.
3. Cov nyhuv tiv thaiv qog
Tam sim no, mob qog noj ntshav yog ib qho ntawm cov kab mob loj heev ntawm tib neeg, uas tau ua rau tib neeg "hais txog mob qog noj ntshav". Nyob rau hauv xyoo tas los no, kev tshawb fawb txog kev tiv thaiv kab mob qog noj ntshav thiab kev ua haujlwm ntawm cordycepin tau dhau los ua lub ntsiab lus kub. Park et al. txiav txim siab txog kev ua haujlwm antitumor ntawm cordycepin los ntawm kev siv cov txheej txheem ntsuas cov qib protein-immunoblotting, thiab pom tias tus naj npawb ntawm apoptotic hlwb tau nce ntau hauv kev sib piv ntawm pab pawg kho mob thiab pab pawg tswj. Nyob rau tib lub sijhawm ntawm cell apoptosis, C6 glioma Cov kev tsiv teb tsaws thiab kev cuam tshuam ntawm cov hlwb kuj raug txo, thiab cov txiaj ntsig kev tshawb fawb tau qhia tias cordycepin tuaj yeem cuam tshuam kev loj hlob ntawm cov qog nqaij hlav cancer los ntawm kev tswj p85/AKT lossis GSK3 -r. Kim et al. pom tias fermented cordycepin mycelia kua muaj zog inhibitory nyhuv ntawm melanoma. Nws tuaj yeem cuam tshuam kev loj hlob ntawm melanoma los ntawm kev txhawb nqa kev qhia ntawm Bax apoptosis protein nyob rau hauv melanoma hlwb.

4. Kev tiv thaiv paj hlwb thiab kev tswj hwm
Cordycepin muaj kev ua haujlwm ntawm neuroprotection thiab kev tswj hwm, thiab tuaj yeem tiv thaiv tsiaj neurons zoo. Jin et al. pom tias cordycepin tuaj yeem txo qhov nce ntawm ROS thiab Ca2+ qib tshwm sim los ntawm glutamate, thiab nws cov nyhuv anti-apoptotic yog ib feem ntawm kev ua kom cov adenosine A1 receptors. Cov txiaj ntsig tau qhia tias cordycepin tuaj yeem yog tus neeg sawv cev kho mob rau cov kab mob neuronal. Chen et al. pom tias cordycepin muaj qhov tseem ceeb neuroprotective nyhuv hauv hypoxic lossis ischemic raug mob. Hauv cov txheej txheem ntawm kev kawm txog cov txheej txheem electrophysiological ntawm cordycepin los tiv thaiv ischemia thiab hypoxic raug mob, nws tau pom tias cordycepin (80 μmol / L) tuaj yeem ncua sijhawm hypoxia-induced membrane depolarization, ua kom ntev lub peev xwm ntawm kev ua haujlwm muaj peev xwm (AP) tua, ncua. sai depolarization tshwm sim. Tsis tas li ntawd, cordycepin kuj tseem ncua qhov kev poob qis ntawm qhov induced AP amplitude los ntawm hypoxia, thiab cov kev tshawb fawb tau ua pov thawj tias cordycepin muaj ib qho tseem ceeb neuroprotective nyhuv tiv thaiv hypoxic raug mob los ntawm kev txhim kho cov electrophysiological muaj nuj nqi ntawm neurons. Tam sim no, neuroinflamation tau raug suav hais tias yog qhov ua rau tseem ceeb ntawm cerebral hemorrhage thiab mob hlwb. Cheng et al. induced cerebral hemorrhage nyob rau hauv cov txiv neej nas los ntawm stereotaxic txhaj ntawm autologous ntshav, thiab ces intraperitoneally muab cordycepin rau cov nas tom qab ua tiav induction ntawm cerebral hemorrhage, thiab pom tias cordycepin tuaj yeem txo cov kev puas siab puas ntsws tom qab cerebral hemorrhage. Kev ua haujlwm tsis txaus, cerebral edema, thiab cov ntaub so ntswg puas nyob ib ncig ntawm hematoma. Tsis tas li ntawd, cordycepin txhim kho neuronal tuag nyob rau hauv cheeb tsam hematoma, qhia tias cordycepin tau ua lub luag haujlwm tiv thaiv neuroprotective hauv ICH qauv. Meng Xuelian pom tias cordycepin tuaj yeem cuam tshuam kev tsim NO hauv microglia, tiv thaiv PC12 neurons, thiab tiv thaiv PC12 hlwb puas los ntawm H2O2 los ntawm kev nce SOD kev ua haujlwm.

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