1.Thaum tshuaj noj nad +

Peb qhov kev pom zoo muab tshuaj ntau npaum li cas yog 100-1200 mg

(Rau cov ncauj lus kom ntxaws ntawm lub hauv paus ntsiab lus thiab kev sim ntawm cov tshuaj pom zoo, koj tuaj yeem tiv tauj Jack yog tias koj xav tau.)

 

2.What yog NAD +?

(Thov nco ntsoov: Lub npe tag nrho ntawm Nicotinamide mononucleotide, thiab tag nrho cov npe ntawm cov piam thaj, thiab cov amino acids acid Nad +.)

 

Nad yog lub sijhawm roj ntsha, lub npe tag nrho yog nicotinamide adenine cinucleotide, lossis coenzyme kuv rau luv dua, nqa mus rau ob tug protons (sau ua nadh + h +).

Nws yog hom hloov hluav taws xob thiab yog cov coenzyme ntawm ntau lub cev ua kom sov, thiab nws txoj haujlwm yog hloov cov txheej txheem metabolic mus rau flavoprotein.

 

3.How Nad + ua haujlwm hauv tib neeg lub cev?

NAD + yog qhov tseem ceeb ntawm cov khoom siv rau kev ua kom acetylase, uas txo nrog lub hnub nyoog.

 

Nad yog coenzyme rau lub dehydrogenases, xws li dej cawv dehydrogenase (ADH), siv los oxidize ethanol. Nws plays ib qho Irreplaceable lub luag haujlwm hauv glycolysis, gluconogenesis, tricarboxylic acid kev voj voog thiab ua pa ua pa. Cov khoom nruab nrab yuav tshaj tawm cov hydrogen rau NAD, ua rau nws nadh.

Nadh ua raws li cov cab kuj hydrogen los ua ke los ua ke ntawm tshuaj lom Osmotic sib txuas hauv kev ua pa.

Nyob rau hauv cov nqe lus ntawm kev nqus lub teeb, Nadh muaj lub ncov siab nqus ntawm 260NM thiab 340nM, thaum NAD muaj qhov tseem ceeb ntawm 2600nM, uas yog ib qho tseem ceeb ntawm tus cwj pwm kom paub qhov txawv ntawm ob. Qhov no tseem yog lub hauv paus rau lub cev rau kev ntsuas metabolic tus nqi hauv ntau cov kev sim metabolic. Qhov nqus tau coefficient ntawm NAD ntawm 260 nm yog 1780 L / (Molm 2012, thaum Nadh ntawm 340 nm yog 6200 L / (MOLM).

NAD + tuaj yeem koom nrog Glycolysis:

C6h12O 6+2 nad {}}}} pi {}} nadh {} h ++2}

Molecular hnyav: 663.4

 

4.What tshwm sim thaum txhawb nqa NAD +?

Cov txiaj ntsig ntawm kev txhawb nqa NAD +

NAD koom nrog kev siv hluav taws xob thiab DNA kho ntawm DNA kho cov khoom siv DNA, thiab lwm yam muaj feem cuam tshuam nrog kev laus txog kev noj qab haus huv.

1) dav faib hauv txhua lub hlwb ntawm tib neeg lub cev, koom nrog cov nqaij qab zib, txhawb nqa cov piam thaj, cov rog thiab cov amino acids, thiab koom nrog synthesis ntawm lub zog. Nws yog ib qho tseem ceeb thiab tseem ceeb coenzyme rau tib neeg lub cev. (Los ntawm Cellular TricarboxLic acid ncig, rog b oxidation, thiab lwm yam

2) NAD + yog tsuas yog substrate rau coenzyme Kuv tau noj cov enzymes (tsuas yog substrate rau lub voj voog adtein adpose synthease CD38 / 157). Txawm li cas los xij, NAD + qib qis hauv lub cev txo kom sai nrog lub hnub nyoog. 50% txo txhua 20 xyoo. Thaum muaj hnub nyoog 40, NAD + qib nyob rau hauv tib neeg lub cev tsuas yog 25% ntawm tus menyuam.

3). Kev ua haujlwm yuav luag txhua cov proteinity nyob rau hauv tib neeg lub cev, thiab ua lub luag haujlwm tseem ceeb hauv cov txheej txheem ntawm cov kev sib pauv ntawm tes, kev hloov kho ntawm tes, agoptosis thiab laus.

4) Lub luag haujlwm ntawm kev tiv thaiv kev noj qab haus huv plawv thiab tiv thaiv kab mob plawv. Yuav luag txhua tag nrho xya subtypes ntawm sirtuins (sirt 1- sirt7) muaj feem xyuam nrog cov kab mob plawv. Sirtuins tau suav tias yog lub hom phiaj hais txog kev mob plawv, tshwj xeeb yog sirt1.

Thiab NAD + yog tsuas yog substrate ntawm sirtuin, raws sij hawm repluishing nad + rau tib neeg lub cev tuaj yeem qhib cov kev ua si ntawm txhua subtype ntawm sirtins.

5) txhim kho cov plaub hau poob. Lub ntsiab ua rau ntawm cov plaub hau poob yog qhov poob ntawm cov kev sib txuas ntawm cov plaub hau cov niam tsev, thiab cov plaub hau ntawm cov plaub hau ua kom muaj zog tiv thaiv plaub hau, yog li poob ntawm kev loj hlob rau kev plaub hau hle plaub hau. Ntxiv rau ntawm NAD + precursor (nmn) tuaj yeem txhawb nqa lub voj voog tricarboxylic muaj cov plaub hau muaj txiaj ntsig zoo los tsim cov plaub hau muaj txiaj ntsig, yog li kev txhim kho cov plaub hau poob.

6) Tiv thaiv daim siab thiab tiv thaiv daim siab mob cancer. Kev tshawb fawb tshiab ntawm Tsinghua University qhia tau tias NMN ntxiv yuav tswj hwm cell lx {(PEGATE} PGDH, thiab}} PGDH, thiab}} PGDH, thiab}} PGDH, thiab}} PGDH, thiab tiv thaiv cov kev tshwm sim ntawm daim siab fibrosis.

Lub siab fibrosis yog ib qho kev teb ntawm daim siab rau daim siab mus rau kev puas tsuaj thiab mob ntev. Yog tias tsis tiv thaiv, nws tuaj yeem yooj yim zuj zus mus rau hauv cov kab mob yooj yim xws li daim siab ua siab thiab mob qog noj ntshav thiab mob qog nqaij hlav cancer.

7) Kev tshawb fawb raws li cov ntaub ntawv tsiaj qhia tias kev siv cov khoom noj kom ua ke ntawm cell kev ua haujlwm, uas yuav tsum txhawb nqa cellors nrog kev txhaj tshuaj tiv thaiv kab mob uas muaj kev txhaj tshuaj tsis zoo. Txawm li cas los xij, txawm hais tias nad + ntxiv nrog kev txhaj tshuaj tiv thaiv kab mob yuav siv tau los ua kev sim ua tib neeg kev sim siab.

 

Tsis tas li ntawd, cov pov thawj tshawb fawb pom tias NAD + kuj ua lub luag haujlwm tseem ceeb hauv cov txiv neej laus, kho kom lub raum puas tsuaj, thiab poob phaus raum.

 

Yog tias tib neeg cov hlwb tsis muaj NAD +, Mitochondrial kev puas tsuaj, kev puas tsuaj DNA muaj peev xwm txo qis, lub siab ntev caj dab protein tsev yog kuj tsis muaj txiaj ntsig, thiab lwm yam. Cov yam tsis zoo no tuaj yeem ua rau muaj mob agoptosis, kev laus, kev laus thiab kev tuag.

 

5.sefity ntawm NAD +

Cov kws tshawb nrhiav ntawm University of Colorado, Boulder tau ua haujlwm pub dawb coj 500 leej ntawm cov neeg tuaj yeem pab dawb ob zaug rau 6 lub lis piam ntawm placebo. Lwm ib nrab ntawm cov neeg ua haujlwm pab dawb tau coj Anwei rau 6 lub lis piam, thiab tom qab ntawd coj Nicotinamide Riboside rau 6 lub lis piam. Cov neeg ua haujlwm pab dawb tau tshaj tawm tsis muaj kev phiv los.

 

Qhov kev sim ua kom pom tias noj cov nicotinamide rows tuaj yeem nce cov ntsiab lus ntawm nicotinamide adenine cinucleotide (NAD +) nyob rau hauv tib neeg lub cev los ntawm 60%. NAD + yog qhov tseem ceeb ntawm cov khoom siv rau kev ua kom acetylase, uas txo nrog lub hnub nyoog. Acetylase tuaj yeem txwv lub cev calorie kom nkag thiab yog qhov zoo rau kev noj qab haus huv.

"Los ntawm kev txhawb nqa Nicotinamide riboside hauv cov laus lawm, peb tsis tau rov qab ua rau cov neeg laus, tab sis tseem ua rau lub cev tawm tsam kev ntxhov siab," tseem muaj kev koom tes hauv txoj kev kawm.

 

Nicotinamide Rujose yog qhov kev tsim ntawm cov vitamin B3, uas muaj nyob rau hauv cov nyiaj hauv cov mis thiab kuj tseem tuaj yeem ua ke.

 

Cov kws tshawb fawb kev ntxhov siab tias lawv cov kev sim yog qhov tsis muaj kev lom zem romoside muaj kev nyab xeeb thiab ua tau zoo, tab sis muab "stepping pob zeb zoo" rau kev tshawb fawb zoo "rau kev tshawb fawb zoo.