glycine ua li cas rau pw tsaug zog?

Glycine (abbreviated li Gly),tseem hu ua aminoacetic acid, yog cov qauv yooj yim ntawm cov amino acids.

Glycine tau tshawb pom hauv xyoo 1820 los ntawm Fab Kis kws tshuaj Henri Braconnot. Glycine yog qab zib li qabzib thiab yog ib qho tseem ceeb ntawm cov amino acid rau tib neeg. Cov kev tshawb fawb tau pom tias glycine muaj kev tswj hwm zoo heev ntawm kev pw tsaug zog, uas feem ntau cuam tshuam nrog cov hauv qab no.

Glycine ib txwm tau suav tias yog qhov tseem ceeb tshaj plaws inhibitory neurotransmitter ntxiv rau GABA (-aminobutyric acid). Nws yog dav faib nyob rau hauv lub hauv nruab nrab lub paj hlwb thiab plays lub luag hauj lwm nyob rau hauv lub kis tau tus mob ntawm paj hlwb thiab kev koom tes nyob rau hauv ntau yam physiological thiab pathological tshwm sim. lub hauv paus tseem ceeb. Glycine pab tiv thaiv kev qaug dab peg thiab kho kev puas siab puas ntsws bipolar, myasthenia gravis thiab lwm yam kab mob. Feem ntau cov kev tshawb fawb qhia tias glycine muaj cov nyhuv calming ntawm lub paj hlwb, uas pab koj so thiab npaj pw tsaug zog.

Cov kws tshawb fawb tau coj 14 tus txiv neej los ua kev tshawb fawb, hais kom lawv noj 3 grams glycine hauv 1 teev ua ntej yuav mus pw, thiab tom qab ntawd ntsuas cov kev hloov hauv lawv lub hlwb nthwv dej thaum pw tsaug zog. Nws tau pom tias cov txiv neej no tau poob rau hauv kev pw tsaug zog sai dua thiab pw tsaug zog ntev dua tom qab noj glycine dua li thaum lawv tsis noj glycine. Cov kws tshawb fawb tau cia 15 tus poj niam ntxhov siab los ntawm insomnia noj 3 grams glycine ua ntej yuav mus pw, thiab thaum lawv sawv ntxov sawv ntxov, lawv txhua tus xav tias lawv tau pw zoo thiab muaj txiaj ntsig zoo rau kev tshem tawm qaug zog. Cov kev sim qhia tau hais tias: tsis zoo li cov tshuaj hypnotic ib txwm muaj, glycine tuaj yeem txo lub sijhawm pw tsaug zog, ua kom lub xeev pw tsaug zog, thiab yuav tsis hloov cov qauv pw tsaug zog.

Cov amino acid me me no muaj zog npaum li cas hauv kev tswj cov txheej txheem nyuaj xws li pw tsaug zog? Ua ntej, qhov ncauj glycine yooj yim nkag mus rau hauv lub hlwb - nws nkag mus rau cov ntshav-hlwb barrier ntawm glycine transporters. Ib zaug hauv lub hlwb, glycine ua rau NMDA receptors (lub npe hu ua N-methyl-D-aspartate receptors) hauv suprachiasmatic nucleus (SCN).
Los ntawm kev hloov kho NMDA receptors hauv SCN, glycine induces systemic vasodilation thiab txhawb kev txo qis hauv lub cev kub. Qhov kub thiab txias tsuas yog ib qho ntawm peb lub cev 24- teev nyob rau hauv ib hnub, thiab thaum hmo ntuj los txog, qhov kub thiab txias yog qhov tseem ceeb rau kev pib pw tsaug zog. Glycine ua haujlwm ntawm thermoregulation zoo ib yam li cov tshuaj noj pw tsaug zog, uas tseem txhawb kev pw tsaug zog los ntawm kev txo qis hauv lub cev kub.

Glycine tau pom tias muaj kev koom tes hauv lwm cov txheej txheem circadian - txhawb kev qhia ntawm arginine vasopressin (AVP) - neuropeptide tsim hauv SCN. Cov kev sim tsiaj tau pom tias nyob rau hauv pab pawg kho glycine, qib qhia ntawm AVP tau nce thaum nruab hnub.
AVP qhia kev sib koom ua ke nrog corticotropin-tso tshuaj hormone (CRH) los txhawb kev tso tawm ntawm adrenocorticotropin (ACTH), uas thaum kawg ua rau kev tsim cov adrenal cortisol, yog li txhawb kev tsaug zog.
Tsis zoo li lwm yam kev pab pw tsaug zog, khoom noj khoom haus lossis tshuaj, nws txhawb kev pw tsaug zog tab sis ua rau koj groggy rau hnub tom qab. Glycine yeej kho qhov qaug zog nruab hnub thiab tsaug zog. Thaum sawv ntxov, cov neeg ua haujlwm pub dawb txwv tsis pub pw tsaug zog tau pom tias muaj kev txhim kho nyob rau hauv cov tshuaj tiv thaiv lub sij hawm ntawm kev ntsuam xyuas ntawm psychomotor ceeb toom thiab qhia tias muaj kev zoo siab dua piv rau pawg placebo.

Glycine yog ib qho tseem ceeb ntawm cov amino acid nyob rau hauv tib neeg, nrog rau kev noj haus yuav tsum kwv yees li ntawm 12 grams ib hnub twg. Muaj ntau yam khoom noj uas muaj glycine, xws li spinach thiab broccoli, thiab lwm yam. Peb tuaj yeem ua kom tau txais glycine los ntawm kev noj zaub mov kom zoo.