● Ergothioneine yog dab tsi?
Ergothioneine (L-Ergothioneine, EGT)yog lub ntuj antioxidant uas tuaj yeem tiv thaiv DNA proteins los ntawm kev puas tsuaj oxidation; Nyob rau tib lub sij hawm raws li ib tug tsis tshua muaj sulfur-muaj amino acid (L-thiohistidine trimethyl internal ntsev), yog ib tug cell tiv thaiv thiab antioxidant ib txwm tshwm sim nyob rau hauv tib neeg lub cev, thiab muaj anti-photoaging thiab anti-oxidation los. Cov qauv molecular yog raws li nram no:
Tab sis peb lub cev tsis tuaj yeem tsim cov ergothioneine ntawm lawv tus kheej, tsuas yog los ntawm kev noj los ntawm kev noj zaub mov thiab sib sau ua ke hauv tib neeg cov ntaub so ntswg thiab hlwb, qhov twg oxidative kev nyuaj siab loj tshaj. Yog li qhov twg yog qhov chaw sab nraud? Ergothioneine yog siab tshaj nyob rau hauv nceb, thiab kuj muaj nyob rau hauv nplej thiab zaub.
● Cov ntsiab lus ntawm ergothioneine hauv cov khoom sib txawv
Ergothioneine feem ntau pom muaj nyob rau hauv actinomycetes (xws li mycobacteria) thiab cov kab mob uas tsis yog cov poov xab (xws li basidiomycota thiab ascomycota), thiab tib neeg lub cev tsuas tuaj yeem tau txais ergothioneine los ntawm kev noj zaub mov. Cov nceb yog cov khoom noj tseem ceeb, tab sis qib Ergothioneine kuj txawv ntawm hom nceb. Txawm hais tias ergothioneine tsuas yog tsim los ntawm qee cov kab mob thiab cov fungi, nws kuj tuaj yeem pom hauv ntau yam khoom noj.
● Kev thauj cov protein OCTN1 pab cov antioxidant ergothioneine kom ua tau zoo
Ergothioneine muaj nyob rau hauv cov tshuaj nyob rau hauv ib tug tautomeric lub xeev ntawm thiol thiab thione, thiab nyob rau hauv lub cev pH, muaj nyob rau hauv daim ntawv ntawm thione nyob rau hauv nruab nrab aqueous daws (thione daim ntawv tiv thaiv autoxidation thiab resonates los ntawm nws daim ntawv qhia muaj zog antioxidant kev ua si).
Paul, B. et al pom tau hais tias raws li ib tug physiological antioxidant cytoprotectant, cov ntaub so ntswg theem ntawm ergothioneine yog tswj los ntawm nws transporter OCTN1, uas muaj peev xwm faib ergothioneine rau cov qe ntshav liab, pob txha, daim siab, raum thiab ob lub qhov muag thiab lwm yam ntaub so ntswg thiab lub cev. Thaum tsis muaj ntxiv ergothioneine, depletion ntawm ergothioneine transporter ua rau txhim kho oxidative puas tsuaj rau cov protein, lipids, thiab DNA thiab nce cell tuag.
Ergothioneine tau zoo dua los tiv thaiv kev tuag ntawm tes ntau dua li qhov sib ntxiv ntawm ascorbate lossis glutathione ntawm tib qhov concentration. Ergothioneine tuaj yeem khaws cia ntau hauv cov hlwb, thiab thaum siv los ua cov tshuaj tiv thaiv antioxidant, nws -SH yog oxidized tab sis tuaj yeem txo qis heev vim yog cov qauv tautomeric tshwj xeeb ntawm cov molecule. Hauv qhov sib piv, glutathione feem ntau yuav luag tag nrho ntawm lub ntsej muag ntawm oxidative kev nyuaj siab. Tsis zoo li polyphenols, ergothioneine raug tso tawm qeeb heev hauv lub cev, yog li ergothioneine tuaj yeem khaws cia hauv cov ntaub so ntswg hauv lub cev thiab cov qe ntshav liab ntawm tib neeg thiab lwm yam tsiaj kom ua tiav nws cov teebmeem.
1) Kev tiv thaiv qhov muag
Ergothioneine muaj nyob rau hauv siab concentrations nyob rau hauv ocular ntaub so ntswg, nrog rau lub lens, retina, cornea, thiab retinal pigment epithelium, thiab yuav txo tau intracellular ROS tiam thiab inhibit oxidation-induced epithelial-mesenchymal hloov los ntawm scavenging chronic reactive oxygen hom (ROS) (EMT) rau pab tiv thaiv qhov muag.
2) kho cov leeg
Ergothioneine tuaj yeem pab tswj kev tawm dag zog kom zoo dua cov leeg nqaij puas tsuaj thiab rov qab los, thiab ergothioneine ntxiv rau 1 lub lis piam txhim kho me ntsis ntawm cov protein synthesis thaum ntxov yam tsis cuam tshuam mitochondrial rov qab.
3) Tiv thaiv lub hlwb kev noj qab haus huv & txhim kho kev txawj ntse
Ergothioneine tuaj yeem tswj hwm kev sib txawv ntawm neuronal, neurogenesis, thiab microglial activation, thiab tseem tuaj yeem tiv thaiv neurotoxicity los ntawm cov kab mob pathogenic los yog tshuaj. Tsis tas li ntawd, cov qib ergothioneine muaj feem xyuam nrog kev paub txog kev ua haujlwm thiab / lossis neurodegeneration hauv tib neeg, ib qho randomized, placebo-tswj, ob-dig muag, kev sib piv-pab pawg hauv tib neeg pom qhov sib txawv, kev tswj qhov ncauj txuas ntxiv ntawm cov nceb extract ntsiav tshuaj uas muaj ergothioneine rau 12 lub lis piam txhim kho. kev txawj ntse muaj nuj nqi.
4) Tiv thaiv UV puas
Ergothioneine tiv thaiv cov hlwb ntawm daim tawv nqaij los ntawm UV rays. Qhov no yuav yog vim ib feem ntawm UV-absorbing zog ntawm ergothioneine, uas kuj tau pom tias muaj kev tiv thaiv los ntawm kev nce qib ntawm cov tshuaj tiv thaiv kab mob endogenous ntawm Nrf2 / ARE hauv tib neeg keratinocytes. Ergothioneine kuj tau pom tias tiv thaiv UV-induced mitochondrial DNA puas.
5) Kev mob plawv
Ergothioneine tuaj yeem cuam tshuam txog kev noj qab haus huv ntawm cov hlab plawv vim tias nws tuaj yeem tiv thaiv cov hlab ntsha endothelium (xws li lub hlwb endothelium), uas tau pom tias tiv thaiv endothelium los ntawm kev puas tsuaj los ntawm paraquat, hydrogen peroxide, qabzib siab, lossis oxidation. Oxidative puas thiab cell tuag induced los ntawm tsawg-density lipoprotein raug.
