Cov hluav taws xob ultraviolet, kev ua qias tuaj ib puag ncig, thiab kev ua neej tsis tu ncua yog lub ntsiab ua rau inducing ntau ntau ntawm reactive oxygen radicals nyob rau hauv daim tawv nqaij. Nyob rau hauv lub sij hawm ntev, nws yuav ua rau cov collagen thiab elastic fibers nyob rau hauv cov ntaub so ntswg ntawm daim tawv nqaij kom so thiab nkig, thiab txo cov efficiency ntawm epidermal cell metabolism, yog li accelerating lub laus txheej txheem. Tam sim no, ntuj antioxidants yog dominating lub lag luam, thiab qee cov ntaub ntawv raw suav nrog ergothioneine, xws li vitamin C, coenzyme Q10 thiab glutathione, tau ntxiv rau cov tshuaj pleev ib ce los tiv thaiv kev laus ua cov khoom xyaw antioxidant zoo.
Ergothioneine, zoo li glutathione, yog thiol, tab sis glutathione tsis ruaj khov. Nyob rau hauv sib piv, ergothioneine feem ntau tshwm sim li thione nyob rau hauv nruab nrab thiab alkaline aqueous daws thiab muaj peev xwm tiv taus nws tus kheej oxidation. Nws tsuas yog oxidized rau disulfide tebchaw nyob rau hauv tej yam kev mob xws li H2O2, Cu2 ntxiv, thiab pH tsawg. Txij li thaum ergothioneine muaj imidazole pawg thiab kuj sulfhydryl pawg, nws ib txwm muaj cov nyhuv antioxidant zoo li glutathione.
Glutathione yog ib qho me me molecule active oligopeptide uas nws cov nyhuv antioxidant nyob ntawm GSH-peroxidase-reductase (GSH-Px-Rx), uas tuaj yeem tshem tawm cov teeb meem dawb radicals thiab lipid peroxides hauv lub cev, yog li tiv thaiv kev laus ntawm daim tawv nqaij thiab cov xim txuam, yog li ci ntsa iab. daim tawv nqaij thiab muab nws ib tug glowing xav.
Tsis zoo li glutathione, daim ntawv tseem ceeb ntawm lysergic acid yog thione, uas tau xav tias yuav ua raws li kev ntxiv rau glutathione hauv lub cev (ntawm chav kawm, yog li muaj peev xwm ferulic acid). Vim tias glutathione yog ib qho polypeptide, nws cov khoom yuav muaj teeb meem tsis tuaj yeem nyob ruaj khov thaum thauj thiab khaws cia. Hauv qhov sib piv, ergothioneine muaj kev ruaj ntseg zoo, uas tuaj yeem ua kom ruaj khov ntawm ergothioneine hauv cov tshuab kom zoo nkauj yam tsis muaj kev cuam tshuam rau kev ruaj ntseg ntawm cov khoom thiab cov khoom zoo, thiab tseem tuaj yeem kov yeej qhov tsis zoo uas glutathione yuav tsis muaj kev ruaj khov thaum lub sij hawm thauj mus los thiab cia. .
Tsis tas li ntawd, ergothioneine tsis oxidize spontaneously nyob rau hauv physiological pH tej yam kev mob. Tib neeg cov tawv nqaij fibroblasts kho nrog ergothioneine pom cov qib peroxide qis tom qab simulated hnub ci UV irradiation, thiab lub peev xwm ntawm cov hlwb nqus, sib sau thiab siv ergothioneine ua rau cov amino acid no thiab nws cov receptors / thauj khoom ib feem ntawm daim tawv nqaij tiv thaiv kab mob antioxidant. Nws inhibits qhov kev qhia ntawm qog necrosis factor- (TNF- ) thiab MMP-1 thiab txo cov qib ROS, uas ua lub luag haujlwm tseem ceeb hauv UV-induced tawv nqaij laus, tshwj xeeb tshaj yog wrinkle tsim.
Ergothioneine yog sulfur-muaj imidazole amino acid. Tib neeg lub cev tsis tuaj yeem tsim cov ergothioneine nws tus kheej, tab sis tsuas yog tuaj yeem nqa nws los ntawm kev noj zaub mov los ntawm nws cov protein thauj khoom OCTN1, thiab nws yog enriched hauv tib neeg cov ntaub so ntswg thiab hlwb. Hais txog kev ua haujlwm lom neeg, ergothioneine yog suav tias yog ib qho tshuaj tiv thaiv kab mob hauv lub cev zoo ib yam li cytoplasmic alcohols thiab glutathione. Glutathione kuj ua raws li antioxidant thiab detoxifier, uas txhais tau hais tias nws yuav pab tshem tawm tej yam teeb meem nyob rau hauv ib sab ntawm lub cev. Nyob rau tib lub sijhawm, ergothioneine tiv thaiv DNA los ntawm kev puas tsuaj oxidative.
