Cov kev tshawb fawb tsis ntev los no tau qhia tiasNad +, raws li ib tug tub ntxhais coenzyme hauv cellular metabolism, yuav cuam tshuam cov kev cai hnyav los ntawm ntau lub tshuab. Raws li kev tshawb fawb molecular tam sim no thiab kev tshawb nrhiav noj tshuaj kho mob, cov ntawv tshawb fawb no tshawb txog lub peev xwm ntawm NAD - hauv kev tswj hwm hnyav.
Molecular hauv paus ntawm cov kev tswj metabolic
NAD + ua si ntawm lub tshuab hluav taws xob muaj nuj nqi hauv lub zog metabolism, thiab nws cov kev xav tau ncaj qha rau cov kev ua tau zoo ntawm TrricarboxLic acid voj voog.

Thaum mitochondrial nad + / Nadh piv txwv ntxiv, cov cell nyiam tsoo cia fatty acids es tsis yog cov rog. Qhov kev tshwm sim no tau tshawb xyuas hauv kev tshawb fawb physiology txuas ntxiv tuaj yeem nce ntxiv NAD + qib hauv cov leeg nqaij los ntawm Lipolytic enzymes [1].
Cov Ntsiab Lus Tseem Ceeb
Sirtuins protein activation
Lub xya sirtin protein nyob rau hauv cov tsiaj txhu txhua tus cia siab rau NAD + kom tau txais kev cuam tshuam rau lawv cov kev cuam tshuam nrog kev ua haujlwm. Ntawm lawv, Sirt1 tau qhia kom txhim kho cov browning hloov pauv ntawm dawb cov ntaub so ntswg thiab nce cov cua sov ua haujlwm ntawm adipocytes los ntawm 3 zaug [2]. Cov txheej txheem no tuaj yeem piav qhia yog vim li cas Nad + precursor ntxiv tuaj yeem txhim kho lub cev rog rog rau cov neeg mob nrog metabolic syndrome.
Mitochondrial biogenesis
NAD + txhawb cov mitochondrial proctation los ntawm kev ua kom lub PGC -1 txoj kab. Cov ntaub ntawv kuaj mob qhia tau tias tom qab 6 lub lis piam ntawm kev txhawb nqa nrog NAD + prechondors hauv cov neeg laus uas tau nce li ntawm 22% thiab cov nyiaj ntawm cov metabolic ntau ntxiv los ntawm 7% [3].
Kev cai tswj hwm qhov tseeb
Mob mob ntev ntau zaus nrog kev rog rog. NAD + txo cov nr-qib-
Cov ntaub ntawv pov thawj tib neeg tib neeg
Kev Kawm Txog Kev Tiv Thaiv

Ib qho 2023 random tswj kev sim ntawm cov neeg rog rog uas tau siv cov roj uas tsis zoo los ntawm cov neeg siv tshuaj tua kab mob ntawm cov neeg ua ke los ntawm kev sib xyaw nrog cov neeg siv tshuaj tiv thaiv kev ua ke
Kev kuaj xyuas kev nyab xeeb
Teb Chaws Asmeskas FDA Qhov Kev Qhia Tawm Tsam Qhov Txheej Txheem Qhia Txog Nad + Cov Tshuaj Tiv Thaiv Tsis Muaj Zog (8%), thiab tus nqi ntawm kev cuam tshuam loj heev yog tsawg dua {3% [6].
Cov ntaub ntawv thov cov lus pom zoo
Koob ntau npaum li cas
Kev kho mob tau txais txiaj ntsig zoo yog nyob rau hauv 250-500 mg / n {mg / ndn nmn. Tsis muaj koob tshuaj-kev sib raug zoo yog qhia sab nraud qhov no [7].
Lub sij hawm qhov rai
Ntxiv ntxiv ntxiv yog ua tau zoo dua li kev ntxiv mus ib hme no
Synergistic zoo
Ua ke nrog cov kev ua kom sib luag ntawm cov nad + tuaj yeem nce ntxiv los ntawm kev tso tshuaj ntxiv tom qab kev qoj ib ce tuaj yeem nce 40% [9].
Kev sib cav thiab cov txwv
Cov kev tshawb fawb nyob tam sim no tsom rau cov teebmeem luv luv thiab tsis muaj cov ntaub ntawv rov qab ntawm ntau tshaj 5 xyoos
Ib Tug Neeg Nrk1 Covene Polymshism yuav cuam tshuam kev hloov zuj zus kev txhawb zog ntawm cov tshuaj hauv 30% ntawm cov pej xeem [10]
Lub purity ntawm cov khoom lag luam muaj sib txawv txawv, thiab kev sim thib peb uas tau hais txog peb cov khoom lag luam uas nquag muaj 60% ntawm tus nqi [11]
Ntawv Sawv cev 1.Yoshino j, li al. Cellag metab. 2021; 33 (6): {1287-1298 2.trammella sa, li al. Nat commour. 2016; 7: 12948 3.Martens Cr, li al. JCI kev pom. 2023; 8 (2): E167893 4.Yoghida m, li al. Kev tshawb fawb. 2019; 363 (6427): 852-857 5.NIT TXIAV TXIM NOCT0482323223260, 2023 6.FDA Cov teeb meem tsis zoo ceeb toom system 2022q4 7. Airhat SE, li al. PLOS ib. 2017; 12 (2): E0186459 8.Levine DC, li al. Kev tshawb fawb. 2022; 378 (6625): {{4 {}} 9.de guia rm, li al. Cell rep. 2019; 27 (10): {{4 4}} 10. RataJczak J, li al. Genes zaubmes. 2016; 11: 3 11.ConsumerLab.com Muab ntaub ntawv qhia ntxiv, 2023





