Lub ntsiab ntawm tib neeg kev laus lus dag nyob rau hauv cell indesen thiab poob hauv cov xov tooj ntawm tes. Thaum muaj hnub nyoog nce, ib qho tseem ceeb ntawm cov cell tsis faib, tiv thaiv cov ntaub so ntswg los ntawm kev txhawb nqa tus kheej {}}} kho. Cov kev ua tiav no suptent cytokines, ua rau mob qog thiab tom qab ntawd ua rau kev laus {}}} cov kab mob uas muaj feem xyuam.
Thaum tsom mus rau ntawm kev siv xyoob ntoo ntawm kev laus, qhov tseeb tau hais los saum toj kawg nkaus sib txuas ntawm ib qho tseem ceeb lwg me me:Nad +Cov. Qhov no coenzyme, ubiquitous nyob rau hauv cov hlwb, tswj qhov sib npaug ntawm lub zog metabolism, kho DNA, thiab kho kom zoo. Lub hnub nyoog {{{2} Qhov kev poob qis hauv Mitochondction, thiab mob siab rau cov khoom noj ntawm cellular ntawm cov lus qhia ua ntej.
Muaj peev xwm los tiv thaiv -}}}}}}}}}}} aging mechanisms ntawm NAD + precursor exterfulaulaation:
Ua kom muaj ntawm Sirtle txoj kev: NAD + yog qhov tseem ceeb cofuins, uas tswj cov noob leagetination, ncua kev ncua ntawm lub selescation thiab txhim kho kev ntxhov siab tsis kam. Hauv kev tshawb nrhiav tsiaj, nce nad + theem txhim kho metabolism thiab txuas ntxiv rau lub neej.
Improvement of Mitochondrial Function: By supporting ATP production and reducing oxidative stress, NAD+ may alleviate age-related mitochondrial dysfunction.
Kho cov kev puas tsuaj DNA: Nad +- Tsis Muaj Tus Thawj Coj Ua Parv Enzymes koom nrog DNA kho. Ntxiv nrog NAD + precursors (piv txwv li, nmn lossis NRG) tau pom tias muaj DNA kev puas tsuaj hauv cov qauv nas.
Nad + anti -} estes
Hauv ntau tus tsiaj qauv, nce NAD + qib tau pom tias muaj anti-}} kev kub ntxhov.
Kev tshawb fawb luam tawm hauv phau ceev xwm txheej ntawm cov kws tshawb fawb ntawm Northwestern University qhia tau tias ib qho enzyme hu ua NDI1 tuaj yeem txuas ntxiv lub neej ntawm cov nas.
Kev tshawb fawb los ntawm Professor David Sinclair Sinclair Sinclair Sinclair Sinclair Sincard hauv 2013 qhia tias NAD + pab txhawb nqa lub neej ntev thiab tswj kev muaj zog.
Nyob rau hauv ib qho kev kho mob xyoo 2014 los ntawm Harvard Center rau kev laus tshuaj, cov tsiaj sib npaug ntawm nad {{}} boosting kev cuam tshuam.
Liposomal encapsulation technology rau kev txhim kho bioavailability
Sheerherb ua haujlwm liposomal encapsulation kom ua kom zoo nad + tus me nyuam thiab cellular uptake:
Mechanism: Liposomes yog phospholipid -}}} Raws li cov hlab plab thiab txhim kho nws txoj kev nqus mus rau hauv cov hlab ntshav
Cov txiaj ntsig:
Lub hom phiaj xa khoom: Liposomes fuse nrog cell nyias nyias, rov tso ncaj qha nad + rau hauv hlwb.
Stability: Tiv thaiv NAD + los ntawm oxidation thiab enzymatic puas, txuas nws txoj kev ua tau zoo.
Ntau dua Bioavailability: kev tshawb fawb qhia txog liposomal formulations tau nce mus txog 90% encapsulation effiential efficiation piv rau cov tshuaj ntsiav sib xyaw.
