Nicotinamide Adenine Dinucleotide hmoov

-Nicotinamide adenine dinucleotide (NAD +)plays lub luag haujlwm tseem ceeb hauv cov metabolism hauv cofactor thiab mobile electron txais. NAD + yog qhov yuav tsum tau oxidizing cosubstrate rau ntau cov enzymes. Nws raug txo rau NADH (Cat# N-035) uas nqa cov electrons mus rau cov khoom siv hluav taws xob thauj mus rau oxidative phorphorylation thiab ATP ntau lawm. NAD + muaj peev xwm pub ADP-ribose moieties rau cov protein, tsim cov nicotinamide hauv cov txheej txheem. Sirtuin enzymes siv NAD + ua lub substrate rau deacetylate proteins thiab ncaj qha kev ua ntawm lub nucleus thiab mitochondria. NAD + yog regenerated los ntawm fermentation thiab oxidative phosphorylation.

NAD + tseem ua lub luag haujlwm tseem ceeb hauv kev tsim hluav taws xob. Hauv Krebs lub voj voog, kev hloov pauv ntawm macronutrients, suav nrog cov protein, rog, thiab carbohydrates, nrog rau cov micronutrients, xws li cov vitamins thiab minerals, rau hauv ATP yuav tsum muaj kev koom tes ntawm NAD +. . Qhov no yog lub zog molecule uas yog qhov tseem ceeb rau kev ua haujlwm ntawm tag nrho cov haujlwm tseem ceeb ntawm tib neeg lub cev.

Tsis tas li ntawd, NAD + yog cofactor nyob rau ntau pua ntawm cov tshuaj tiv thaiv enzymatic uas muaj xws li:

•Immune cell signaling thiab tiv thaiv kab mob

• Txo qhov mob

•Production ntawm telomeres, ncua lub neej ntawm telomeres

•Neurotransmitter ntau lawm

• Noj qab nyob zoo circadian rhythms thiab pw tsaug zog

• Txhim khu kev ua haujlwm ntawm lub neej ntev

• Tiv thaiv cov hlab ntsha puas tsuaj thiab txo kev pheej hmoo ntawm kab mob plawv

• Noj qab nyob zoo laus

1. NAD+ thiab circadian atherosclerosis
Kev tswj hwm lub moos lom neeg muaj feem cuam tshuam rau ntau yam kab mob, suav nrog tab sis tsis txwv rau kev pw tsaug zog, ntshav qab zib, thiab qog nqaij hlav. Ntau cov txheej txheem pathological tau tshwm sim los ntawm circadian moos teeb meem, uas tej zaum yuav yog caj ces lossis ib puag ncig. Hauv luv luv, ua kom lub moos circadian ua haujlwm kom zoo ua lub luag haujlwm tseem ceeb hauv kev saib xyuas kev noj qab haus huv.
2. NAD+ thiab lub paj hlwb
Sirtuins yog nicotinamide adenine dinucleotide (NAD +)-nyob deacylases uas tau ib txwm cuam tshuam txog kev txwv caloric thiab kev laus hauv cov tsiaj. Cov proteins no kuj tseem ua lub luag haujlwm tseem ceeb hauv kev tswj hwm kev noj qab haus huv neuronal thaum laus.
3. NAD+ thiab lub siab ua haujlwm
Enzymes nyob rau hauv NAD + kev taw qhia txoj hauv kev paub txog kev tiv thaiv lub siab los ntawm kev rog rog, fibrosis thiab insulin tsis kam, uas yog txhua yam cuam tshuam nrog kev loj hlob ntawm cov kab mob rog rog.
4. NAD+ thiab lub raum ua haujlwm
Kev txo qis hauv NAD + qib thiab qhov sib piv ntawm cov kev ua sirtuin hauv cov neeg laus lub raum yog lub luag haujlwm loj rau lub hnub nyoog cuam tshuam txog kev ua haujlwm ntawm lub raum thiab ua raws.
5. NAD+ thiab cov leeg pob txha
Piv nrog rau cov nas me me, cov nas tau txo qis cov leeg nqaij atrophy thiab o, nrog rau cov cim qhia ntawm insulin thiab lub peev xwm ntawm insulin los txhawb cov piam thaj. Kev kho mob ntawm cov nas hnub nyoog nrog NAD + precursors txhim kho cov leeg nqaij.
6. NAD+ thiab lub plawv ua haujlwm
NAD + qib yog qhov tseem ceeb rau kev ua haujlwm hauv lub plawv thiab rov qab los tom qab raug mob. Ntawm tag nrho cov NAD+-nyob ntawm cov cim qhia cov protein, SIRT3 zoo li yog qhov tseem ceeb tshaj plaws.
7. NAD+ thiab vascular endothelial hlwb
Endothelial cell (EC) senescence yog cov txheej txheem pathophysiological ntawm cov qauv thiab kev ua haujlwm hloov pauv, suav nrog dysregulation ntawm vascular tone, nce endothelial permeability, arteriosclerosis, impaired angiogenesis thiab vascular kho, thiab txo EC mitochondrial biogenesis. Cov kev tshawb fawb tau lees paub tias qhov nce ntawm NAD + thiab SIRT1 tuaj yeem txhim kho kev loj hlob ntawm cov hlab ntsha, thim rov qab vascular laus, thiab txo cov cell tuag.
8. NAD+ thiab cov kab mob metabolic
NAD + tuaj yeem txhim kho kev rog rog, mob ntshav qab zib me me, thiab kev tiv thaiv kev yug menyuam los ntawm kev cuam tshuam ntawm cov rog metabolism thiab cov piam thaj metabolism. Nws tuaj yeem txhim kho qhov tsis zoo ntawm cov niam rog rog ntawm kev yug me nyuam ntawm poj niam xeeb tub.

Koj tuaj yeem hu rau peb los ntawm emailChriswang@sheerherb.comlos yog xa koj cov kev xav tau rau hauv qab ntawm nplooj ntawv no. Peb yuav zoo siab los pab koj!